C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

Ítems similars

• Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.
  per: Matuoka, K, et al.
  Publicat: (1992)
• Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.
  per: Matuoka, K, et al.
  Publicat: (1993)
• Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity.
  per: Gotoh, N, et al.
  Publicat: (1994)
• CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells.
  per: Matsuda, M, et al.
  Publicat: (1994)
• Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.
  per: Tanaka, S, et al.
  Publicat: (1993)