TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer

Tumor budding in colorectal cancer is likened to an epithelial-mesenchymal transition (EMT) characterized predominantly by loss of E-cadherin and up-regulation of E-cadherin repressors like TWIST1 and TWIST2. Here we investigate a possible epigenetic link between TWIST proteins and the tumor budding...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Galván, José A., Helbling, Melina, Koelzer, Viktor H., Tschan, Mario P., Berger, Martin D., Hädrich, Marion, Schnüriger, Beat, Karamitopoulou, Eva, Dawson, Heather, Inderbitzin, Daniel, Lugli, Alessandro, Zlobec, Inti
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359262/
https://ncbi.nlm.nih.gov/pubmed/25528769
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