Investigation of IL-23 (p19, p40) and IL-23R identifies nuclear expression of IL-23 p19 as a favorable prognostic factor in colorectal cancer: a retrospective multicenter study of 675 patients

IL-23 is a heterodimeric cytokine involved in inflammatory diseases; its role in cancer progression is controversial. Here we analyse the expression of IL-23 subunits (p40 and p19) and IL-23R in colorectal cancer with regard to disease progression, clinical-pathological and molecular aspects. Immuno...

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Autors principals: Helbling, Melina, Lukesch, Anne, Haimovici, Aladin, Karamitopoulou, Eva, Berger, Martin D., Hädrich, Marion, Mallaev, Makhmud, Schnüriger, Beat, Koelzer, Viktor H., Dawson, Heather, Borner, Markus, Langer, Rupert, Rosenberg, Robert, Nitsche, Ulrich, Inderbitzin, Daniel, Lugli, Alessandro, Tschan, Mario P., Zlobec, Inti
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Clinical Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148090/
https://ncbi.nlm.nih.gov/pubmed/25015728
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