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Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS
High-grade serous ovarian cancers (HGSOC) are genomically complex, heterogeneous cancers with a high mortality rate, due to acquired chemoresistance and lack of targeted therapy options. Cyclin-dependent kinase inhibitors (CDKi) target the retinoblastoma (RB) signaling network, and have been success...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | Oncotarget |
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Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Impact Journals LLC
2014
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4359249/ https://ncbi.nlm.nih.gov/pubmed/25557169 |
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