PIK3CA mutations in non-small cell lung cancer (NSCLC): Genetic heterogeneity, prognostic impact and incidence of prior malignancies

Background: Somatic mutations of the PIK3CA gene have been described in non-small cell lung cancer (NSCLC), but limited data is available on their biological relevance. This study was performed to characterize PIK3CA-mutated NSCLC clinically and genetically. Patients and methods: Tumor tissue collec...

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Pubblicato in:Oncotarget
Autori principali: Scheffler, Matthias, Bos, Marc, Gardizi, Masyar, König, Katharina, Michels, Sebastian, Fassunke, Jana, Heydt, Carina, Künstlinger, Helen, Ihle, Michaela, Ueckeroth, Frank, Albus, Kerstin, Serke, Monika, Gerigk, Ulrich, Schulte, Wolfgang, Töpelt, Karin, Nogova, Lucia, Zander, Thomas, Engel-Riedel, Walburga, Stoelben, Erich, Ko, Yon-Dschun, Randerath, Winfried, Kaminsky, Britta, Panse, Jens, Becker, Carolin, Hellmich, Martin, Merkelbach-Bruse, Sabine, Heukamp, Lukas C., Büttner, Reinhard, Wolf, Jürgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
Soggetti:
Clinical Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359235/
https://ncbi.nlm.nih.gov/pubmed/25473901
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