Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia

Chronic myeloid leukemia in the blastic phase (CML-BP) responds poorly to clinical treatments and is usually fatal. In this study, we found that the histone H3 lysine 4 (H3K4) demethylase RBP2 (also called JARID1A and KDM5A) is underexpressed in CML-BP. The RBP2 histone demethylase stimulates leukem...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Zhou, Minran, Zeng, Jiping, Wang, Xiaoming, Wang, Xiangyu, Huang, Tao, Fu, Yue, Sun, Ting, Jia, Jihui, Chen, Chunyan
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359230/
https://ncbi.nlm.nih.gov/pubmed/25575817
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