Cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis patients on a hybrid motoneuron cell line.

Patients with amyotrophic lateral sclerosis possess antibodies (ALS IgGs) that bind to L-type skeletal muscle voltage-gated calcium channels (VGCCs) and inhibit L-type calcium current. To determine whether interaction of ALS IgGs with neuronal VGCCs might influence motoneuron survival, we used a mot...

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Autors principals: Smith, R G, Alexianu, M E, Crawford, G, Nyormoi, O, Stefani, E, Appel, S H
Format: Artigo
Idioma:Inglês
Publicat: 1994
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC43583/
https://ncbi.nlm.nih.gov/pubmed/8159758
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