The Extracellular A-loop of Dual Oxidases Affects the Specificity of Reactive Oxygen Species Release

NADPH oxidase (Nox) family proteins produce superoxide (O(2)(⨪)) directly by transferring an electron to molecular oxygen. Dual oxidases (Duoxes) also produce an O(2)(⨪) intermediate, although the final species secreted by mature Duoxes is H(2)O(2), suggesting that intramolecular O(2)(⨪) dismutation...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ueyama, Takehiko, Sakuma, Megumi, Ninoyu, Yuzuru, Hamada, Takeshi, Dupuy, Corinne, Geiszt, Miklós, Leto, Thomas L., Saito, Naoaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358283/
https://ncbi.nlm.nih.gov/pubmed/25586178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.592717
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