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A novel endonuclease that may be responsible for damaged DNA base repair in Pyrococcus furiosus
DNA is constantly damaged by endogenous and environmental influences. Deaminated adenine (hypoxanthine) tends to pair with cytosine and leads to the A:T→G:C transition mutation during DNA replication. Endonuclease V (EndoV) hydrolyzes the second phosphodiester bond 3′ from deoxyinosine in the DNA st...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357722/ https://ncbi.nlm.nih.gov/pubmed/25694513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv121 |
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