G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway

We recently identified a novel GPCR-dependent pathway for regulation of cardiac hypertrophy that depends on Golgi phosphatidylinositol 4-phosphate (PI4P) hydrolysis by a specific isoform of phospholipase C (PLC), PLCε, at the nuclear envelope. How stimuli are transmitted from cell surface GPCRs to a...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Malik, S., deRubio, R. G., Trembley, M., Irannejad, R., Wedegaertner, P. B., Smrcka, A. V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357516/
https://ncbi.nlm.nih.gov/pubmed/25609085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-10-1476
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