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Applying the logic of genetic interaction to discover small molecules that functionally interact with human disease alleles
Despite rapid advances in the genetics of complex human diseases, understanding the significance of human disease alleles remains a critical roadblock to clinical translation. Here, we present a chemical biology approach that uses perturbation with small molecules of known mechanism to reveal mechan...
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| Publicado no: | Methods Mol Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357233/ https://ncbi.nlm.nih.gov/pubmed/25618333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-2269-7_2 |
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