Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway

BACKGROUND: Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator in cancer cell survival, epithelial-mesenchymal transition, and tumorigenesis. Inhibition of EZH2 has become a promising therapeutic option for various human malignancies. Previously, we demonstrated that the EZH2/miR-30d/k...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Zhang, Pingyu, Yang, Xianbin, Ma, Xiaoyan, Ingram, Davis R, Lazar, Alexander J, Torres, Keila E, Pollock, Raphael E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357176/
https://ncbi.nlm.nih.gov/pubmed/25890085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0325-1
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