A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations

Protein kinases represent central and multifunctional regulators of a balanced virus-host interaction. Cyclin-dependent protein kinase 7 (CDK7) plays crucial regulatory roles in cell cycle and transcription, both connected with the replication of many viruses. Previously, we developed a CDK7 inhibit...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Hutterer, Corina, Eickhoff, Jan, Milbradt, Jens, Korn, Klaus, Zeitträger, Isabel, Bahsi, Hanife, Wagner, Sabrina, Zischinsky, Gunther, Wolf, Alexander, Degenhart, Carsten, Unger, Anke, Baumann, Matthias, Klebl, Bert, Marschall, Manfred
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356785/
https://ncbi.nlm.nih.gov/pubmed/25624324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04534-14
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