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Inhibition of Protein Synthesis and Malaria Parasite Development by Drug Targeting of Methionyl-tRNA Synthetases

Aminoacyl-tRNA synthetases (aaRSs) are housekeeping enzymes that couple cognate tRNAs with amino acids to transmit genomic information for protein translation. The Plasmodium falciparum nuclear genome encodes two P. falciparum methionyl-tRNA synthetases (PfMRS), termed PfMRS(cyt) and PfMRS(api). Phy...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Hussain, Tahir, Yogavel, Manickam, Sharma, Amit
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356764/
https://ncbi.nlm.nih.gov/pubmed/25583729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02220-13
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