Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects

Recent evidence shows that Alzheimer disease (AD) dementia in the oldest-old subjects was associated with significantly less amyloid plaque and fibrillary tangle neuropathology than in the young-old population. In this study, using quantitative (q) PCR studies, we validated genome-wide microarray RN...

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Veröffentlicht in:Neuropsychiatr Dis Treat
Hauptverfasser: Zhao, Wei, Wang, Jun, Varghese, Merina, Ho, Lap, Mazzola, Paolo, Haroutunian, Vahram, Katsel, Pavel L, Gibson, Gary E, Levine, Samara, Dubner, Lauren, Pasinetti, Giulio Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2015
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356684/
https://ncbi.nlm.nih.gov/pubmed/25784811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/NDT.S74898
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