Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats

Acute treatment with positive allosteric modulators (PAMs) of mGlu1 and mGlu5 metabotropic glutamate receptors (RO0711401 and VU0360172, respectively) reduces the incidence of spike-and wave discharges in the WAG/Rij rat model of absence epilepsy. However, from the therapeutic standpoint, it was imp...

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Publicat a:Neuropharmacology
Autors principals: D’Amore, V., Santolini, I., Celli, R., Lionetto, L., De Fusco, A., Simmaco, M., van Rijn, C.M., Vieira, E., Stauffer, S.R., Conn, P.J., Bosco, P., Nicoletti, F., van Luijtelaar, G., Ngomba, R.T.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356528/
https://ncbi.nlm.nih.gov/pubmed/24859611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.05.005
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