Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats

Absence epilepsy is generated by the cortico-thalamo-cortical network, which undergoes a finely tuned regulation by metabotropic glutamate (mGlu) receptors. We have shown previously that potentiation of mGlu1 receptors reduces spontaneous occurring spike and wave discharges (SWDs) in the WAG/Rij rat...

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Hauptverfasser: D’Amore, V., Santolini, I., van Rijn, C.M., Biagioni, F., Molinaro, G., Prete, A., Conn, P.J., Lindsley, C.W., Zhou, Y., Vinson, P.N., Rodriguez, A.L., Jones, C.K., Stauffer, S.R., Nicoletti, F., van Luijtelaar, G., Ngomba, R.T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787880/
https://ncbi.nlm.nih.gov/pubmed/22705340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.05.044
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