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Characterization of three alternative transcripts of the BRCA1 gene in patients with breast cancer and a family history of breast and/or ovarian cancer who tested negative for pathogenic mutations

The study of BRCA1 and BRCA2 genes and their alterations has been essential to the understanding of the development of familial breast and ovarian cancers. Many of the variants identified have an unknown pathogenic significance. These include variants which determine alternative mRNA splicing, ident...

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Bibliografski detalji
Izdano u:Int J Mol Med
Glavni autori: GAMBINO, GAETANA, TANCREDI, MARIELLA, FALASCHI, ELISABETTA, ARETINI, PAOLO, CALIGO, MARIA ADELAIDE
Format: Artigo
Jezik:Inglês
Izdano: D.A. Spandidos 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356434/
https://ncbi.nlm.nih.gov/pubmed/25683334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2015.2103
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