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CD44 functions in Wnt signaling by regulating LRP6 localization and activation
Wnt reception at the membrane is complex and not fully understood. CD44 is a major Wnt target gene in the intestine and is essential for Wnt-induced tumor progression in colorectal cancer. Here we show that CD44 acts as a positive regulator of the Wnt receptor complex. Downregulation of CD44 express...
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| Izdano u: | Cell Death Differ |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356338/ https://ncbi.nlm.nih.gov/pubmed/25301071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.156 |
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