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CD44 functions in Wnt signaling by regulating LRP6 localization and activation

Wnt reception at the membrane is complex and not fully understood. CD44 is a major Wnt target gene in the intestine and is essential for Wnt-induced tumor progression in colorectal cancer. Here we show that CD44 acts as a positive regulator of the Wnt receptor complex. Downregulation of CD44 express...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Schmitt, M, Metzger, M, Gradl, D, Davidson, G, Orian-Rousseau, V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356338/
https://ncbi.nlm.nih.gov/pubmed/25301071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.156
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