Functional Consequences of Perturbed CXCL12 Signal Processing: Analyses of Immature Hematopoiesis in GRK6-Deficient Mice

Hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow (BM) in an environment rich in CXCL12, the ligand for CXCR4, which is constitutively expressed on all immature hematopoietic cells in BM. This ligand-receptor pair critically controls HSPC retention and (relative) quiescence in BM...

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Detalles Bibliográficos
Publicado en:Stem Cells Dev
Autores principales: Chudziak, Doreen, Spohn, Gabriele, Karpova, Darja, Dauber, Katrin, Wiercinska, Eliza, Miettinen, Johanna A., Papayannopoulou, Thalia, Bönig, Halvard
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Original Research Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356183/
https://ncbi.nlm.nih.gov/pubmed/25316534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0284
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