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Functional Consequences of Perturbed CXCL12 Signal Processing: Analyses of Immature Hematopoiesis in GRK6-Deficient Mice
Hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow (BM) in an environment rich in CXCL12, the ligand for CXCR4, which is constitutively expressed on all immature hematopoietic cells in BM. This ligand-receptor pair critically controls HSPC retention and (relative) quiescence in BM...
Gespeichert in:
Veröffentlicht in: | Stem Cells Dev |
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Hauptverfasser: | , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
Mary Ann Liebert, Inc.
2015
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356183/ https://ncbi.nlm.nih.gov/pubmed/25316534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0284 |
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