Functional Consequences of Perturbed CXCL12 Signal Processing: Analyses of Immature Hematopoiesis in GRK6-Deficient Mice

Hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow (BM) in an environment rich in CXCL12, the ligand for CXCR4, which is constitutively expressed on all immature hematopoietic cells in BM. This ligand-receptor pair critically controls HSPC retention and (relative) quiescence in BM...

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Sparad:
Bibliografiska uppgifter
I publikationen:Stem Cells Dev
Huvudupphovsmän: Chudziak, Doreen, Spohn, Gabriele, Karpova, Darja, Dauber, Katrin, Wiercinska, Eliza, Miettinen, Johanna A., Papayannopoulou, Thalia, Bönig, Halvard
Materialtyp: Artigo
Språk:Inglês
Publicerad: Mary Ann Liebert, Inc. 2015
Ämnen:
Original Research Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356183/
https://ncbi.nlm.nih.gov/pubmed/25316534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0284
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