Functional Consequences of Perturbed CXCL12 Signal Processing: Analyses of Immature Hematopoiesis in GRK6-Deficient Mice

Hematopoietic stem and progenitor cells (HSPCs) reside in bone marrow (BM) in an environment rich in CXCL12, the ligand for CXCR4, which is constitutively expressed on all immature hematopoietic cells in BM. This ligand-receptor pair critically controls HSPC retention and (relative) quiescence in BM...

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Dades bibliogràfiques
Publicat a:Stem Cells Dev
Autors principals: Chudziak, Doreen, Spohn, Gabriele, Karpova, Darja, Dauber, Katrin, Wiercinska, Eliza, Miettinen, Johanna A., Papayannopoulou, Thalia, Bönig, Halvard
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2015
Matèries:
Original Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356183/
https://ncbi.nlm.nih.gov/pubmed/25316534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0284
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