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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

beta-Amyloid is a 39- to 43-amino-acid neurotoxic peptide that aggregates to form the core of Alzheimer disease-associated senile (amyloid) plaques. No satisfactory hypothesis has yet been proposed to explain the mechanism of beta-amyloid aggregation and toxicity. We present mass spectrometric and e...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Hensley, K, Carney, J M, Mattson, M P, Aksenova, M, Harris, M, Wu, J F, Floyd, R A, Butterfield, D A
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1994
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43558/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8159737/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.8.3270
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