Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42

A key event in Alzheimer's disease (AD) pathogenesis is the conversion of the peptide beta-amyloid (Aβ) from its soluble monomeric form into various aggregated morphologies in the brain. Preventing aggregation of Aβ is being actively pursued as a primary therapeutic strategy for treating AD. Trehalo...

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Hlavní autoři:	Ruitian Liu, Hedieh Barkhordarian, Sharareh Emadi, Chan Beum Park, Michael R. Sierks
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2005-10-01
Edice:	Neurobiology of Disease
Témata:	Alzheimer's disease Beta-amyloid Trehalose Aggregation Atomic force microscope Cytotoxicity
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0969996105000628
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