Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet, when WASP function is eliminated there is ne...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kumari, Sudha, Depoil, David, Martinelli, Roberta, Judokusumo, Edward, Carmona, Guillaume, Gertler, Frank B, Kam, Lance C, Carman, Christopher V, Burkhardt, Janis K, Irvine, Darrell J, Dustin, Michael L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355629/
https://ncbi.nlm.nih.gov/pubmed/25758716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04953
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