Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet, when WASP function is eliminated there is ne...

詳細記述

保存先:
書誌詳細
出版年:eLife
主要な著者: Kumari, Sudha, Depoil, David, Martinelli, Roberta, Judokusumo, Edward, Carmona, Guillaume, Gertler, Frank B, Kam, Lance C, Carman, Christopher V, Burkhardt, Janis K, Irvine, Darrell J, Dustin, Michael L
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2015
主題:
Cell Biology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355629/
https://ncbi.nlm.nih.gov/pubmed/25758716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04953
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