PPARγ depletion stimulates Nox4 expression and human pulmonary artery smooth muscle cell proliferation

Hypoxia stimulates pulmonary hypertension (PH) in part by increasing the proliferation of pulmonary vascular wall cells. Recent evidence suggests that signaling events involved in hypoxia-induced cell proliferation include sustained nuclear factor-kappaB (NF-κB) activation, increased NADPH oxidase 4...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Bijli, Kaiser M., Kleinhenz, Jennifer M., Murphy, Tamara C., Kang, Bum-Yong, Adesina, Sherry E., Sutliff, Roy L., Hart, C. Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355175/
https://ncbi.nlm.nih.gov/pubmed/25557278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.12.019
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