Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A

OBJECTIVE: Glucagon-like peptide 1 (GLP-1) enhances insulin secretion and protects β-cell mass. Diabetes therapies targeting the GLP-1 receptor (GLP-1R), expressed in numerous tissues, have diminished dose-response in patients with type 2 diabetes compared with healthy human controls. The aim of thi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Rajan, Sindhu, Dickson, Lorna M., Mathew, Elizabeth, Orr, Caitlin M.O., Ellenbroek, Johanne H., Philipson, Louis H., Wicksteed, Barton
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354925/
https://ncbi.nlm.nih.gov/pubmed/25830090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.01.010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados