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SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion
Glucagon-like peptide-1 (GLP-1)-based incretin therapy is becoming central to the treatment of type 2 diabetes. Activation of incretin hormone receptors results in rapid elevation of cAMP followed by enhanced insulin secretion. However, the incretin effect may be significantly impaired in diabetes....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3311292/ https://ncbi.nlm.nih.gov/pubmed/22234371 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00486.2011 |
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