Inhibition of Bcl-2 Sensitizes Mitochondrial Permeability Transition Pore (MPTP) Opening in Ischemia-Damaged Mitochondria

BACKGROUND: Mitochondria are critical to cardiac injury during reperfusion as a result of damage sustained during ischemia, including the loss of bcl-2. We asked if bcl-2 depletion not only leads to selective permeation of the outer mitochondrial membrane (MOMP) favoring cytochrome c release and pro...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Chen, Qun, Xu, Haishan, Xu, Aijun, Ross, Thomas, Bowler, Elizabeth, Hu, Ying, Lesnefsky, Edward J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354902/
https://ncbi.nlm.nih.gov/pubmed/25756500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118834
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