Calcium Elevation in Mitochondria Is the Main Ca(2+) Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening

We have investigated in detail the role of intra-organelle Ca(2+) content during induction of apoptosis by the oxidant menadione while changing and monitoring the Ca(2+) load of endoplasmic reticulum (ER), mitochondria, and acidic organelles. Menadione causes production of reactive oxygen species, i...

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Bibliografiske detaljer
Main Authors: Baumgartner, Heidi K., Gerasimenko, Julia V., Thorne, Christopher, Ferdek, Pawel, Pozzan, Tullio, Tepikin, Alexei V., Petersen, Ole H., Sutton, Robert, Watson, Alastair J. M., Gerasimenko, Oleg V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742844/
https://ncbi.nlm.nih.gov/pubmed/19515844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025353
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