Targeting IL-17B–IL-17RB signaling with an anti–IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines

Pancreatic cancer has an extremely high mortality rate due to its aggressive metastatic nature. Resolving the underlying mechanisms will be crucial for treatment. Here, we found that overexpression of IL-17B receptor (IL-17RB) strongly correlated with postoperative metastasis and inversely correlate...

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Udgivet i:J Exp Med
Main Authors: Wu, Heng-Hsiung, Hwang-Verslues, Wendy W., Lee, Wen-Hsin, Huang, Chun-Kai, Wei, Pei-Chi, Chen, Chia-Lin, Shew, Jin-Yuh, Lee, Eva Y.-H.P., Jeng, Yung-Ming, Tien, Yu-Wen, Ma, Che, Lee, Wen-Hwa
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354366/
https://ncbi.nlm.nih.gov/pubmed/25732306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141702
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