TREM2 deficiency eliminates TREM2(+) inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. However, the cell types and mechanisms underlying TREM2’s involvement in neurodegeneration remain to be established. Here, we report that TREM2 is...

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發表在:J Exp Med
Main Authors: Jay, Taylor R., Miller, Crystal M., Cheng, Paul J., Graham, Leah C., Bemiller, Shane, Broihier, Margaret L., Xu, Guixiang, Margevicius, Daniel, Karlo, J. Colleen, Sousa, Gregory L., Cotleur, Anne C., Butovsky, Oleg, Bekris, Lynn, Staugaitis, Susan M., Leverenz, James B., Pimplikar, Sanjay W., Landreth, Gary E., Howell, Gareth R., Ransohoff, Richard M., Lamb, Bruce T.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2015
主題:
Brief Definitive Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354365/
https://ncbi.nlm.nih.gov/pubmed/25732305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142322
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