Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer

KRAS mutations are a major cause of drug resistance to molecular-targeted therapies. Aberrant epidermal growth factor receptor (EGFR) signaling may cause dysregulation of microRNA (miRNA) and gene regulatory networks, which leads to cancer initiation and progression. To address the functional releva...

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Bibliografiska uppgifter
I publikationen:Mol Ther Nucleic Acids
Huvudupphovsmän: Hiraki, Masayuki, Nishimura, Junichi, Takahashi, Hidekazu, Wu, Xin, Takahashi, Yusuke, Miyo, Masaaki, Nishida, Naohiro, Uemura, Mamoru, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Soh, Jae-Won, Doki, Yuichiro, Mori, Masaki, Yamamoto, Hirofumi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354340/
https://ncbi.nlm.nih.gov/pubmed/25756961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.5
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