Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer

KRAS mutations are a major cause of drug resistance to molecular-targeted therapies. Aberrant epidermal growth factor receptor (EGFR) signaling may cause dysregulation of microRNA (miRNA) and gene regulatory networks, which leads to cancer initiation and progression. To address the functional releva...

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Detalles Bibliográficos
Publicado en:Mol Ther Nucleic Acids
Main Authors: Hiraki, Masayuki, Nishimura, Junichi, Takahashi, Hidekazu, Wu, Xin, Takahashi, Yusuke, Miyo, Masaaki, Nishida, Naohiro, Uemura, Mamoru, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Soh, Jae-Won, Doki, Yuichiro, Mori, Masaki, Yamamoto, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354340/
https://ncbi.nlm.nih.gov/pubmed/25756961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2015.5
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