Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells

Cyclin-dependent kinases 4 and 6 (CDK4/6) in complex with D-type cyclins promote cell cycle entry. Most human cancers contain overactive CDK4/6-cyclin D, and CDK4/6-specific inhibitors are promising anti-cancer therapeutics. Here, we investigate the critical functions of CDK4/6-cyclin D kinases, sta...

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Udgivet i:Nat Commun
Main Authors: The, Inge, Ruijtenberg, Suzan, Bouchet, Benjamin P., Cristobal, Alba, Prinsen, Martine B. W., van Mourik, Tim, Koreth, John, Xu, Huihong, Heck, Albert J. R., Akhmanova, Anna, Cuppen, Edwin, Boxem, Mike, Muñoz, Javier, van den Heuvel, Sander
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354291/
https://ncbi.nlm.nih.gov/pubmed/25562820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6906
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