Exogenous Superoxide Dismutase Mimetic Without Scavenging H(2)O(2) Causes Photoreceptor Damage in a Rat Model for Oxygen-Induced Retinopathy

PURPOSE. Frequent, brief intermittent episodes of hypoxia (IH) during hyperoxia increase reactive oxygen species in the immature retina with compromised antioxidant systems, thus leading to oxygen-induced retinopathy (OIR). We examined the hypothesis that early exposure to a mimetic of superoxide di...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Jivabhai Patel, Shamin, Bany-Mohammed, Fayez, McNally, Lois, Valencia, Gloria B., Lazzaro, Douglas R., Aranda, Jacob V., Beharry, Kay D.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354243/
https://ncbi.nlm.nih.gov/pubmed/25670494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-15321
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