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Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.

The immunosuppressant drug FK506 acts by binding to receptor proteins, FK506-binding proteins (FKBPs), which in turn can bind to and regulate a Ca(2+)-dependent phosphatase, calcineurin, and a Ca2+ release channel, the ryanodine receptor. Based on our findings in regeneration models that levels of F...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lyons, W E, George, E B, Dawson, T M, Steiner, J P, Snyder, S H
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1994
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC43541/
https://ncbi.nlm.nih.gov/pubmed/7512727
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