Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.
The immunosuppressant drug FK506 acts by binding to receptor proteins, FK506-binding proteins (FKBPs), which in turn can bind to and regulate a Ca(2+)-dependent phosphatase, calcineurin, and a Ca2+ release channel, the ryanodine receptor. Based on our findings in regeneration models that levels of F...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43541/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512727/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.8.3191 |
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