Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.

The immunosuppressant drug FK506 acts by binding to receptor proteins, FK506-binding proteins (FKBPs), which in turn can bind to and regulate a Ca(2+)-dependent phosphatase, calcineurin, and a Ca2+ release channel, the ryanodine receptor. Based on our findings in regeneration models that levels of F...

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Main Authors: Lyons, W E, George, E B, Dawson, T M, Steiner, J P, Snyder, S H
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC43541/
https://ncbi.nlm.nih.gov/pubmed/7512727
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