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Facilitation of endoglin-targeting cancer therapy by development/utilization of a novel genetically engineered mouse model expressing humanized endoglin (CD105)

Endoglin (ENG) is a TGF-β coreceptor and essential for vascular development and angiogenesis. A chimeric antihuman ENG (hENG) monoclonal antibody (mAb) c-SN6j (also known as TRC105) shows promising safety and clinical efficacy features in multiple clinical trials of patients with various advanced so...

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Bibliografiska uppgifter
I publikationen:Int J Cancer
Huvudupphovsmän: Toi, Hirofumi, Tsujie, Masanori, Haruta, Yuro, Fujita, Kanako, Duzen, Jill, Seon, Ben K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353567/
https://ncbi.nlm.nih.gov/pubmed/24866768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28994
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