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Crystal structure of afadin PDZ domain–nectin-3 complex shows the structural plasticity of the ligand-binding site

Afadin, a scaffold protein localized in adherens junctions (AJs), links nectins to the actin cytoskeleton. Nectins are the major cell adhesion molecules of AJs. At the initial stage of cell–cell junction formation, the nectin–afadin interaction plays an indispensable role in AJ biogenesis via recrui...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Fujiwara, Yoshie, Goda, Natsuko, Tamashiro, Tomonari, Narita, Hirotaka, Satomura, Kaori, Tenno, Takeshi, Nakagawa, Atsushi, Oda, Masayuki, Suzuki, Mamoru, Sakisaka, Toshiaki, Takai, Yoshimi, Hiroaki, Hidekazu
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353363/
https://ncbi.nlm.nih.gov/pubmed/25534554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2628
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