Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses

ROBO1, fibronectin Type-III domain (Fn)-containing protein, is a novel immunotherapeutic target for hepatocellular carcinoma in humans. The crystal structure of the antigen-binding fragment (Fab) of B2212A, the monoclonal antibody against the third Fn domain (Fn3) of ROBO1, was determined in pursuit...

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Veröffentlicht in:Protein Sci
Hauptverfasser: Nakayama, Taisuke, Mizohata, Eiichi, Yamashita, Takefumi, Nagatoishi, Satoru, Nakakido, Makoto, Iwanari, Hiroko, Mochizuki, Yasuhiro, Kado, Yuji, Yokota, Yuki, Satoh, Reiko, Tsumoto, Kouhei, Fujitani, Hideaki, Kodama, Tatsuhiko, Hamakubo, Takao, Inoue, Tsuyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353359/
https://ncbi.nlm.nih.gov/pubmed/25492858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2619
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