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Targeting hypoxia at the forefront of anticancer immune responses

Hypoxia influences immune checkpoint receptors and their respective ligands. In support, we recently demonstrated that hypoxia selectively upregulates programmed cell death ligand 1 (PD-L1) on myeloid-derived suppressor cells (MDSCs) via hypoxia inducible factor 1 α (HIF-1α) binding to a hypoxia-res...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Noman, Muhammad Zaeem, Chouaib, Salem
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353170/
https://ncbi.nlm.nih.gov/pubmed/25964858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.954463
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