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Reversal of natural killer cell exhaustion by TIM-3 blockade

Natural killer (NK) cells are innate immune cells that become progressively exhausted in advanced stage cancer, crippling their ability to execute antitumor functions. We previously characterized the nature of NK cell exhaustion in metastatic melanoma patients, reporting a correlation with high expr...

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Pubblicato in:Oncoimmunology
Autori principali: Gallois, Anne, Silva, Ines, Osman, Iman, Bhardwaj, Nina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353130/
https://ncbi.nlm.nih.gov/pubmed/25964857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.946365
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