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Reversal of natural killer cell exhaustion by TIM-3 blockade

Natural killer (NK) cells are innate immune cells that become progressively exhausted in advanced stage cancer, crippling their ability to execute antitumor functions. We previously characterized the nature of NK cell exhaustion in metastatic melanoma patients, reporting a correlation with high expr...

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Publicat a:Oncoimmunology
Autors principals: Gallois, Anne, Silva, Ines, Osman, Iman, Bhardwaj, Nina
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353130/
https://ncbi.nlm.nih.gov/pubmed/25964857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.946365
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