HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is strongly correlated with poor neurological status, the maintenance of white matter integrity is poorly understood,...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Wang, Guohua, Shi, Yejie, Jiang, Xiaoyan, Leak, Rehana K., Hu, Xiaoming, Wu, Yun, Pu, Hongjian, Li, Wei-Wei, Tang, Bo, Wang, Yun, Gao, Yanqin, Zheng, Ping, Bennett, Michael V. L., Chen, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352818/
https://ncbi.nlm.nih.gov/pubmed/25691750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501441112
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