HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is strongly correlated with poor neurological status, the maintenance of white matter integrity is poorly understood,...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wang, Guohua, Shi, Yejie, Jiang, Xiaoyan, Leak, Rehana K., Hu, Xiaoming, Wu, Yun, Pu, Hongjian, Li, Wei-Wei, Tang, Bo, Wang, Yun, Gao, Yanqin, Zheng, Ping, Bennett, Michael V. L., Chen, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352818/
https://ncbi.nlm.nih.gov/pubmed/25691750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501441112
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi