HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is strongly correlated with poor neurological status, the maintenance of white matter integrity is poorly understood,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Guohua, Shi, Yejie, Jiang, Xiaoyan, Leak, Rehana K., Hu, Xiaoming, Wu, Yun, Pu, Hongjian, Li, Wei-Wei, Tang, Bo, Wang, Yun, Gao, Yanqin, Zheng, Ping, Bennett, Michael V. L., Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352818/
https://ncbi.nlm.nih.gov/pubmed/25691750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501441112
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