HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

Severe traumatic brain injury (TBI) elicits destruction of both gray and white matter, which is exacerbated by secondary proinflammatory responses. Although white matter injury (WMI) is strongly correlated with poor neurological status, the maintenance of white matter integrity is poorly understood,...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Wang, Guohua, Shi, Yejie, Jiang, Xiaoyan, Leak, Rehana K., Hu, Xiaoming, Wu, Yun, Pu, Hongjian, Li, Wei-Wei, Tang, Bo, Wang, Yun, Gao, Yanqin, Zheng, Ping, Bennett, Michael V. L., Chen, Jun
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352818/
https://ncbi.nlm.nih.gov/pubmed/25691750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501441112
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