Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

Deubiquitinating enzymes (DUBs) control vital processes in eukaryotes by hydrolyzing ubiquitin adducts. Their activities are tightly regulated, but the mechanisms remain elusive. In particular, the DUB UCH-L5 can be either activated or inhibited by conserved regulatory proteins RPN13 and INO80G, res...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Sahtoe, Danny D., van Dijk, Willem J., El Oualid, Farid, Ekkebus, Reggy, Ovaa, Huib, Sixma, Titia K.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352763/
https://ncbi.nlm.nih.gov/pubmed/25702870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.039
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