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Curcumin Attenuates Opioid Tolerance and Dependence by Inhibiting Ca(2+)/Calmodulin-Dependent Protein Kinase II α Activity
Chronic use of opioid analgesics has been hindered by the development of opioid addiction and tolerance. We have reported that curcumin, a natural flavonoid from the rhizome of Curcuma longa, attenuated opioid tolerance, although the underlying mechanism remains unclear. In this study, we tested the...
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| Publicado en: | J Pharmacol Exp Ther |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4352596/ https://ncbi.nlm.nih.gov/pubmed/25515789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.219303 |
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