Il10 deficiency re-balances innate immunity to mitigate Alzheimer-like pathology

The impact of inflammation suppressor pathways on Alzheimer’s disease (AD) evolution remains poorly understood. Human evidence suggests involvement of the cardinal anti-inflammatory cytokine, interleukin-10 (Il10). We crossed the APP/PS1 mouse model of cerebral amyloidosis with a mouse deficient in...

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Bibliographic Details
Published in:Neuron
Main Authors: Guillot-Sestier, Marie-Victoire, Doty, Kevin Richard, Gate, David, Rodriguez, Javier, Yan Leung, Brian Pak, Rezai-Zadeh, Kavon, Town, Terrence
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352138/
https://ncbi.nlm.nih.gov/pubmed/25619654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.068
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